Institut für Klinische Pharmakologie
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Dörr J*, Gregor L*, Lacher SB*, Oner A, Sun Y, Piseddu I, Fertig L, Spajic S, Lesch S, Michaelides S, Seifert M, Gottschlich A, Samson N, Majed L, Briukhovetska D, Simnica D, Hartmann V, Gabriel K, Cohen S, Boland GM, Andreu-Sanz D, Carlini E, Stock S, Holtermann A, Müller PJ, Strzalkowski T, Trefny MP, Endres S, Jenkins RW, Böttcher JP, Kobold S. Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours. Nat Biomed Eng. 2026 Feb 11. doi: 10.1038/s41551-025-01610-6. Epub ahead of print. PMID: 41673138. *Contributed equally. IF: 26.6 


Gottschlich A*#, Grünmeier R*, Hoffmann GV*, Nandi S*, Kavaka V, Müller PJ, Jobst J, Oner A, Kaiser R, Gärtig J, Piseddu I, Frenz-Wiessner S, Fairley SD, Schulz H, Igl V, Janert TA, Di Fina L, Mulkers M, Thomas M, Briukhovetska D, Simnica D, Carlini E, Tsiverioti CA, Trefny MP, Lorenzini T, Märkl F, Mesquita P, Brabenec R, Strzalkowski T, Stock S, Michaelides S, Hellmuth J, Thelen M, Reinke S, Klapper W, Gelebart PF, Nicolai L, Marr C, Beltrán E, Megens RTA, Klein C, Baran-Marszak F, Rosenwald A, von Bergwelt-Baildon M, Bröckelmann PJ, Endres S, Kobold S#. Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma. Blood. 2025 Apr 3;145(14):1536-1552. doi: 10.1182/blood.2023022197. PMID: 40178843; PMCID: PMC12002222. *Contributed equally. # Corresponding authors. IF2024 23.1


Lacher SB*, Dörr J*, de Almeida GP, Hönninger J, Bayerl F, Hirschberger A, Pedde AM, Meiser P, Ramsauer L, Rudolph TJ, Spranger N, Morotti M, Grimm AJ, Jarosch S, Oner A, Gregor L, Lesch S, Michaelides S, Fertig L, Briukhovetska D, Majed L, Stock S, Busch DH, Buchholz VR, Knolle PA, Zehn D, Dangaj Laniti D, Kobold S#, Böttcher JP#. PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells. Nature. 2024 May;629(8011):417-425. doi: 10.1038/s41586-024-07254-x. Epub 2024 Apr 24. PMID: 38658748; PMCID: PMC11078747. *Contributed equally. # Corresponding authors. IF2024 48.5


Märkl F*, Schultheiß C*, Ali M, Chen SS, Zintchenko M, Egli L, Mietz J, Chijioke O, Paschold L, Spajic S, Holtermann A, Dörr J, Stock S, Zingg A, Läubli H, Piseddu I, Anz D, Minden MD, Zhang T, Nerreter T, Hudecek M, Minguet S, Chiorazzi N, Kobold S#, Binder M#. Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia. Nat Commun. 2024 Feb 2;15(1):993. doi: 10.1038/s41467-024-45378-w. PMID: 38307904; PMCID: PMC10837166. *Contributed equally. # Corresponding authors. IF2024 15.7


Wagenbauer KF*, Pham N*, Gottschlich A*, Kick B*, Kozina V, Frank C, Trninic D, Stömmer P, Grünmeier R, Carlini E, Tsiverioti CA, Kobold S#, Funke JJ#, Dietz H#. Programmable multispecific DNA-origami-based T-cell engagers. Nat Nanotechnol. 2023 Nov;18(11):1319-1326. doi: 10.1038/s41565-023-01471-7. Epub 2023 Aug 17. PMID: 37591933; PMCID: PMC10656288. *Contributed equally. # Corresponding authors. IF2024 34.9. 

Gottschlich A*, Thomas M*, Grünmeier R*, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti Ch, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller P, Dörr J, Seifert M, Cadilha B, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner Ch, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C#, Kobold S#. Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia. Nat Biotechnol. 2023 Nov;41(11):1618-1632. doi: 10.1038/s41587-023-01684-0. Epub 2023 Mar 13. PMID: 36914885; PMCID: PMC7615296. *Contributed equally. # Joint supervision. IF2021 68.2

Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou A, Schuebel M, Jobst J, Zhang T, Doerr J, Mearkl F, Majed L, Meuller PJ, May P, Gottschlich A, Tokarew N, Leucke J, Oener A, Schwerdtfeger M, Andreu-Sanz D, Gruenmeier R, Seifert M, Michaelides S, Hristov M, Koenig LM, Cadilha B, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell R, Cerezo-Wallis D, Tejedo C, Soengas M, Bald T, Huber S, Endres S, Kobold S.
T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity. 2023 Jan 10;56(1):143-161.e11. doi: 10.1016/j.immuni.2022.12.010. PMID: 36630913; PMCID: PMC9839367. IF2021 43.5

Boehmer D, Formisano S, de Oliveira Mann C, Mueller S, Kluge M, Metzger P, Rohlfs M, Hörth Ch, Kocheise L, Lichtenthaler S, Hopfner KP, Endres S, Rothenfusser S, Friedel C, Duewell P, Schnurr* M, Koenig* L.
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. Sci Immunol. 2021 Jul 16;6(61):eabe2550. doi: 10.1126/sciimmunol.abe2550. PMID: 34272227. *Contributed equally. IF2021 30.6

https://www.lmu-klinikum.de/aktuelles/pressemitteilungen/programmierter-zelltod-von-tumorzellen-durch-synthetische-rna-molekule/3b1205f11defadda

Di Pilato M*, Kfuri-Rubens R*, Pruessmann J*, Ozga AJ*, Messemaker M, Cadilha B, Sivakumar R, Cianciaruso Ch, Warner RD, Marangoni F, Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F, Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ, Mempel TR. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021 Aug 19;184(17):4512-4530.e22. doi: 10.1016/j.cell.2021.07.015. Epub 2021 Aug 2. PMID: 34343496; PMCID: PMC8719451. *Contributed equally. IF2021 66.

Lesch S*, Blumenberg V*, Stoiber S, Gottschlich A, Ogonek J, Cadilha B, Dantes Z, Rataj F, Dorman K, Lutz J, Karches C, Heise C, Kurzay M, Larimer B, Grassmann S, Rapp M, Nottebrock A, Kruger S, Tokarew N, Metzger P, Hoerth Ch, Benmebarek MR, Dhoqina D, Gruenmeier R, Seifert M, Oener A, Umut Ö, . . . Rothenfusser S, Duewell P, Koenig L, Schnurr M, Subklewe M, Liss A, Halama N, Reichert M, Mempel T, Endres S, Kobold S. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nat Biomed Eng. 2021 Nov;5(11):1246-1260. doi: 10.1038/s41551-021-00737-6. Epub 2021 Jun 3. PMID: 34083764; PMCID: PMC7611996. *Contributed equally. IF2020 29.2

https://www.lmu-klinikum.de/aktuelles/pressemitteilungen/neue-strategie-gegen-bauchspeicheldrusenkrebs/f95d2c0d7ad55197

Kobold* S, Grassmann* S, Chaloupka M, Lampert C, Wenk S, Kraus F, Rapp M, Duewell P, Zeng Y, Schmollinger J, Schnurr M, Endres S#, Rothenfußer S#. Impact of a new fusion receptor on PD-1-mediated immunosuppression in adoptive T cell therapy. J Natl Cancer Inst. 2015 Jun 23;107(8):djv146. doi: 10.1093/jnci/djv146. PMID: 26105028; PMCID: PMC4609553. IF 15.2

Kobold S, Steffen J, Chaloupka M, Grassmann S, Henkel J, Castoldi R, Zeng Y, Chmielewski M, Schmollinger J, Schnurr M, Rothenfußer S, Schendel DJ, Abken H, Sustmann C, Niederfellner CG, Klein C, Bourquin C, Endres S.
Selective bispecific T cell recruiting antibody enhances anti-tumor activity of adoptive T cell transfer.  J Natl Cancer Inst. 2014 Nov 24;107(1):364. doi: 10.1093/jnci/dju364. PMID: 25424197. IF 15.2

Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J.
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Erratum in: Nat Immunol. 2014 Jan;15(1):109. PMID: 19915568. IF 26.2

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschlaeger N, Endres S, Tardivel A, Tschopp J, Ruland J.
Syk kinase signaling couples to the Nalp3 inflammasome for anti-fungal host defense. Nature. 2009 May 21;459(7245):433-6. doi: 10.1038/nature07965. Epub 2009 Apr 1. PMID: 19339971. IF 38.6

Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzel-mann KK, Schlee M, Endres S, Hartmann G. 5’-triphosphate RNA is the ligand for RIG-I. Science. 2006 Nov 10;314(5801):994-7. doi: 10.1126/science.1132505. Epub 2006 Oct 12. PMID: 17038590. IF 35.3

Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G. Sequence-specific potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005 Mar;11(3):263-70. doi: 10.1038/nm1191. Epub 2005 Feb 20. PMID: 15723075. IF 30.6