Results colloquium

Xinyue Zhou, AG Helfrich

Melanoma cells-derived small extracellular vesicles drive neutrophil-mediated immune suppression

Journal club

Giulia Rappa, AG Subklewe

n.a

Results colloquium

Helen Stirling, AG Rothenfußer

Investigating neutralising antibodies following yellow fever vaccination.

Journal club

Naima Gierlichs, AG Kobold

Reiss et al. CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial, Nature Medicine 2025

Educational colloquium

Dr. Bernhard Ransmayr

Gene hunting: The study of rare inborn errors of immunity

Journal club

Emre Erdogan, AG Kobold

Cancelled

Results colloquium

Ziting Zhang, AG Helfrich

Investigating the contribution of NCAM1 to melanoma brain colonization

Journal club

Annika Jasper, AG Buchner

Hou et al. A portable poison exon for small-molecule control of mammalian gene expression, Nature Methods 2025

Guest speaker

Prof. Michael Lotze
University of Pittsburgh

The science of tumor infiltrating lymphocytes (TIL)

Results colloquium

Anja Surla, AG Rothenfußer

Transcriptional and genetic determinants of early antiviral immunity following yellow fever vaccination

Journal club

Vona Ludovica, AG Theurich

Hecht et al. Catabolism of extracellular glutathione supplies cysteine to support tumour, Nature 2026

Results colloquium

Thomas Janert, AG Kobold

Cotargeting atypical B cells in CAR T cell therapy of AML

Journal club

Zhang Ziting, AG Helfrich

Rodriguez-Baena et al. Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases, Cancer Cell 2025

Introduction round

Educational colloquium

Dr. Maria Bengoa, AG Rothenfußer

Platelet signatures as predictive biomarkers of YF17D-vaccine response

Results colloquium

Annika Jasper, AG Buchner

The role of ENPP1 in multiple myeloma progression and immune surveillance

Journal club

Selin Sogukcelik, AG Rothenfußer

Vadivel et al. Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, Blood 2024

Guest speaker

Dr. Mirco J. Friedrich, Hematology and Immune Engineering, Deutsches Krebsforschungszentrum (DKFZ) 

Engineering immune resilience to target cancer and aging

Results colloquium

Jakob Harwood, AG Kobold

Tumor-agnostic improvement of cellular therapies through drug-inducible chemokine receptor (DrICk-R) engineering

Journal club

Pauline Michael-Kuschel, AG Kim-Hellmuth

Tutino et al. Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes, Nature Communications 2025

Results colloquium

Giulia Rappa, AG Subklewe

Generation of antigen specific T cells to fight acute myeloid leukemia

Journal club

Linda Hammann, AG Anz

Zhong et al. TGF-β-mediated crosstalk between TIGIT+Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes Nat. Commun. 2024

Guest speaker

Prof. Dr. Elvira Mass
Life and Medical Sciences Institute, University of Bonn

Developmental programming of tissue-resident macrophages

Results colloquium

Nilofer Razak, AG König/Schnurr

Exploring neutrophil subpopulations in pancreatic ductal adenocarcinoma

Journal club

Lilli Ballheimer, AG Kobold

Gu et al. Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity, Cell 2026

Results colloquium

David Andreu Sanz

RoseTTAFold enables design of novel targeting moieties and next-generation CAR T cells

Journal club

Catharina Witte, AG Anz

De Leon et al. An ultrasmall core–shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments, Nature Nanotechnology 2025

Results colloquium

Linda Hammann, AG Anz

The impact of CCR4 ligands on regulatory T cells in islet autoimmunity

Journal club

Mara Henrich, AG Kobold

Cabezas-Caballero et al. Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors, Nature Biomedical Engineering 2026

Results colloquium

Nilofer Razak, AG König Schnurr

Exploring neutrophil subpopulations in pancreatic ductal adenocarcinoma

Journal club

Aleksandra Jucha, AG Kim-Hellmuth

Yang et al. Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma, Nature Communications 2025

Educational colloquium

Dr. Daria Briukhovetska, AG Kobold

IL-10 and IL-22 in the tumor microenvironment: duality, dysregulation, and therapeutic leverage

Journal club

Stefan Niedermeier, AG Buchner

Dai et al. Multi-modal spatial characterization of tumor immune microenvironments identifies targetable inflammatory niches in diffuse large B  cell lymphoma, Nature Genetics 2025

Journal club

Helen Stirling, AG Rothenfußer

de los Rios Kobara et al. Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2, Nature Immunology 2025

Distribution of team jobs for 2026

Guest speaker

Assistant Professor Paul Bourgine

Lund University

Human mini bones for modeling leukemia and immunotherapy response

Results colloquium

Wendy den Hartog, AG Kobold

CAR-iMGL against Alzheimer's disease: Development and characterization of anti-Aβ CARs

Journal club

Xinyue Zhou, AG Helfrich

Rodriguez-Baena et al. Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases, Cancer Cell 2025

Results colloquium

Till Johannsmann, AG Daniel

Novel inducers of regulatory T cells to control autoimmune T1D

Journal club

Emre Erdogan, AG Kobold

Rotiroti et al. Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy, Nature Cancer 2025

Results colloquium

Charlotte Carcopino, AG Kobold

Arming NK cells with a chimeric antigen receptor for the treatment of acute myeloid leukemia

Journal club

Adriano Carboniero, AG Theurich

Neo et al. Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis. Sci. Transl. Med. 2024

Results colloquium

Stefan Niedermeier, AG Buchner

Exploring ferroptosis as a novel therapeutic strategy in Richter transformation

Journal club

Julia Teppert, AG König-Schnurr

Grippin et al. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade, Nature 2025

Results colloquium

Amelie Muth, AG Subklewe

Understanding the influence of glucocorticoids on T-cell-recruiting bispecific antibodies in B-cell malignancies

Journal club

Adriano Carboniero, AG Theurich

Cancelled

Guest speaker

Dr. Claudio Sustmann

Roche Diagnostics Gmbh

Trends for Bi- and Multispecific Antibodies - a deep dive into the journey to Brainshuttle^TM

Educational colloquium

Dr. Lisa Arnold, AG Heinzerling

Therapeutic role of extracorporeal photopheresis in the management of immune-related adverse events

Journal club

Nilofer Abdul Razak, AG König-Schnurr

Garner et al. Understanding and reversing mammary tumordriven reprogramming of myelopoiesis to reduce metastatic spread, Cancer Cell 2025

Results colloquium

Amar Hadzic, AG Theurich

CD98 overexpression increases T cell memory formation and immunity

Journal club

David Andreu Sanz, AG Kobold

Chen et al. Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery, Nature 2025

Guest speaker

Prof. Sascha Dietrich

University Hospital of Düsseldorf

Multimodal spatial profiling of lymph node microenvironment - insights for therapy

Results colloquium

Ludovica Vona, AG Theurich

Establishment of a solute carrier protein (SLC)-wide CRISPR gain-of-function screen to improve T-cell properties in cancer immunotherapy

Journal club

Kathrin Großhauser, AG Kobold

Geraghty et al. Immunotherapy-related cognitive impairment after CAR T cell therapy in mice, Cell 2025

Results colloquium

Rasmus Müller, AG Kobold

5-HTR induced CART Metabotraction to enhance anti-tumor efficacy

Journal club

Jakob Harwood, AG Kobold

Piraner et al. Engineered receptors for soluble cellular communication and disease sensing, Nature 2025

Results colloquium

Emanuele Carlini, AG Kobold

Enhancing CAR-T cell function with a novel cytokine switch receptor

Journal club

Sandra Dirschl, AG Daniel

Lim et al. PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma, Nature Immunology 2025 

Results colloquium

Helen Stirling, AG Rothenfußer

Investigating neutralizing antibodies following yellow fever vaccination

Journal club

Emanuele Carlini, AG Kobold

Stahl et al. CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma, Cancer Cell 2025

Results colloquium

Emre Erdogan, AG Kobold

Development of a CAR that specifically and selectively recognizes AML blasts

Journal club

Wendy den Hartog, AG Kobold

Kimura et al. Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease, Nature 2025

Results colloquium

Kathrin Großhauser, AG Kobold

Identification and validation of novel therapeutic strategies to control CAR T cell function

Journal club

Giulia Rappa, AG Subklewe

Borgers et al. Personalized, autologous neoantigen-specific T cell therapy in metastatic melanoma: A phase 1 trial, Nature Medicine 2025

Results colloquium

Alexandra Jucha, AG Kim-Hellmuth

Dissecting dendritic cell heterogeneity with single-cell multiomics

Journal club

Charlotte Carcopino, AG Kobold

Li et al. Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering, Science Advances 2023

Guest speaker

PD Dr. Christian Klein

Zürich, Schweiz

Development of bispecific antibodies and antibody fusion proteins for cancer immunotherapy

Journal club

Mara Henrich, AG Kobold

Tian et al. CCR5 and IL‑12 co‑expression in CAR T cells improves antitumor efficacy by reprogramming tumor microenvironment in solid tumors, Cancer Immunol Immunother 2025

Results colloquium

Sandra Dirschl, AG Daniel

Regulatory T cell impairments evolve prior to the onset of beta cell autoimmunity

Journal club

Annika Jasper, AG Buchner

Wang et al. STING agonist-based ER-targeting molecules boost antigen cross-presentation, Nature 2025

Results colloquium

Annika Jasper, AG Buchner

The role of ENPP1 in multiple myeloma progression and immune surveillance

Journal club

Linda Hammann, AG Anz

Cancelled

Guest speaker

Dr. med. Michael Bscheider

Principal Scientist, Roche Holding AG

Human in vitro immunology in drug development

Results colloquium

Jakob Harwood, AG Kobold

Tumor-agnostic improvement of cellular therapies through drug-inducible chemokine receptor (DrICk-R) engineering

Journal club

Seoyoung Jang, AG Kobold

Reiss et al. CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: A phase 1 trial, Nature Medicine 2025

Guest speaker

Sébastien Wälchli, PhD

Senior scientist, group leader, Oslo University Hospital

Establishment of the first CAR factory in Norway

Results colloquium

Adriano Carboniero, AG Theurich

Modification of the functional and anti-cancer profile of Natural Killer cells subpopulations in the context of obesity and exercise

Journal club

Florian Jahrbeck, AG Rothenfußer

Cheng et al. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences, Nature Immunology 2023