News | 05/03/2026
Breakthrough in Autoimmune Therapy

Blinatumomab Shows Promise in Rare, Life-Threatening Combined Autoimmune Disorders. Congratulations Adrian!

LMU University Hospital team publishes landmark case in New England Journal of Medicine, opening new perspectives for refractory ITP and APS
Adrian Gottschlich just described the use of the bispecific CD3 x CD19 antibody blinatumomab as a treatment in a rare but severe combined autoimmune disorder or immune thrombocytopenia and anti-phospholipide syndrome in the New England Journal of Medicine

A team at LMU University Hospital has reported a groundbreaking therapeutic success in a patient suffering from the rare and potentially life-threatening combination of immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS). In a study published on 5 March 2026 in the New England Journal of Medicine, Adrian Gottschlich (Inst. for Clinical Pharmacology - AG Kobold) and colleagues describe the targeted use of the bispecific CD3×CD19 antibody blinatumomab to silence the underlying autoimmune response in a therapy-resistant case.

Congratulations to Adrian Gottschlich and the LMU team on opening new perspectives for the treatment of severe autoimmune diseases.

Gottschlich, A., Bücklein, V., El-Marouk, K., Kaiser, R., Schmid, M., Janert Thomas, A., Winkelmann, M., Ziemann, F., Hänel, G., Handtke, S., Thiele, T., Wichmann, C., Kobold, S., Zugmaier, G., Rausch, C., Schulze-Koops, H., Lindner Lars, H., Spiekermann, K., von Bergwelt-Baildon, M., & Subklewe, M. (2026). Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome. New England Journal of Medicine, 394(10), 1030-1033. doi:10.1056/NEJMc2516228

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